Vriligy 60 mg, containing the active ingredient dapoxetine, is used to treat premature ejaculation. It can interact with various medications, potentially leading to adverse effects or reduced efficacy. Here are some important interactions to be aware of:
- Monoamine Oxidase Inhibitors (MAOIs): Using dapoxetine with MAOIs can cause serious, even life-threatening interactions. A washout period of at least 14 days is recommended after stopping an MAOI before starting dapoxetine and vice versa.
- Other SSRIs or SNRIs: Combining dapoxetine with other selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) can increase the risk of serotonin syndrome, a potentially serious condition.
- Thioridazine: This antipsychotic drug should not be used with dapoxetine, as it can lead to significant cardiac effects.
- PDE5 Inhibitors: Using dapoxetine with medications for erectile dysfunction like sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) should be done with caution due to the potential for additive effects on blood pressure and fainting.
- CYP3A4 Inhibitors: Drugs that strongly inhibit CYP3A4, such as ketoconazole, ritonavir, and erythromycin, can increase dapoxetine levels in the blood, leading to higher risk of side effects.
- CNS Active Medications: Alcohol and other central nervous system depressants may enhance the sedation and dizziness caused by dapoxetine.
- Blood Thinners: Warfarin and other anticoagulants may have their effects altered when taken with dapoxetine.
- Herbal Supplements: St. John's Wort, which is often used for depression, may reduce the efficacy of dapoxetine.